Wednesday, August 16, 2017

Cortisol & DHEA

Cortisol is a stress hormone produced by the adrenals. This hormone is released when you experience stress and is an important hormone in your body working to maintain homeostasis by determining your energy needs.

DHEA is a base hormone used to manufacture all of the steroid hormones. Levels deplete after the age of 25. DHEA effectively antagonizes the effects of cortisol. Low levels of DHEA are often found in those with adrenal fatigue.

The ratio between cortisol and DHEA has numerous effects on the body. An elevated ratio (high cortisol) can lead to suppressed immune function, impaired metabolism, loss of memory, breakdown of collagen and bone, and other undesirable effects.




Increased cortisol levels causes the body to access protein stores to create energy, which blocks the effect of insulin leading to increased insulin resistance. Cortisol also can cause stored triglycerides to be relocated to the visceral fat cells, primarily the ones in the abdomen and under muscle.

If you struggle with insulin resistance or obesity, elevated cortisol may be the cause. If that is the case, DHEA could be the cure.








McEvoy, M. (2011). Cortisol & DHEA: The Major Hormone Balance. Retrieved from: https://metabolichealing.com/cortisol-dhea-the-major-hormone-balance/

DeLacey, E. Cortisol, Stress and Body Fat. Retrieved from: http://www.fitday.com/fitness-articles/nutrition/healthy-eating/cortisol-stress-and-body-fat-myth-versus-fact.html

Wednesday, August 9, 2017

Hydroxycitric Acid

Bio-Citrin - Garcinia Cambogia with Bioperine and Chromium Polynicotinate  

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Helps with long-term weight management by minimizing the impact of carbohydrates. The hydroxycitric acid (HCA) from Garcinia Cambogia blocks the enzyme ATP-citrate lyase, which is responsible for converting carbohydrates to fat. This allows more glucose to be used by the cells as energy, while decreasing the amount of new fat produced and increasing satiety.

Hydroxycitric acid has been proven in multiple studies to be a safe and effective weight loss ingredient which suppresses appetite and inhibits fat synthesis.

Read more about the benefits of HCA in our newest white paper: Carbohydrate Metabolism - Slowing Lipid Synthesis. 

 

Monday, July 17, 2017

Dieting & Your Immune System

Your immune system helps guard your body from germs, viruses, and other threats. Ongoing stress can take its toll on your immune system making you more vulnerable to colds and flu. The impact stress has on your immune system was observed in medical students during a 10 year study1:

"Researchers found that the students' immunity went down every year under the simple stress of the three-day exam period. Test takers had fewer natural killer cells, which fight tumors and viral infections. They almost stopped producing immunity-boosting gamma interferon and infection-fighting T-cells responded only weakly to test-tube stimulation."

Stress can be caused by many factors, including dieting. Studies have found that dieters produced higher levels of the harmful stress hormone cortisol2. In addition to dieting being a large cause of stress, a restricted diet may further reduce the effectiveness of your immune system due to nutrient deficiencies.

For the above reasons it is important for dieters to supplement their immune system with nutrients they may not be getting in their diet.

Immuneplex™ is a unique formulation with the purpose of aiding the immune system with
essential vitamins and minerals required for proper function.







References:
1. Kiecolt-Glaser, J. K., Glaser, R. (1993). Mind and immunity. Mind/Body Medicine (pp. 39-59). New York: Consumer Reports.

2. Hagan, P. (2010). Dieting really CAN harm your health. Daily Mail UK. Retrieved from: http://www.dailymail.co.uk/health/article-1266591/Dieting-really-CAN-harm-health-Slimmers-higher-risk-heart-disease-cancer.html

Friday, June 23, 2017

Oral vs. Sublingual

When you swallow a pill, it travels through your gastrointestinal tract. It passes through the stomach, the intestines, and the liver before the medication is delivered to where it is needed. Sublingual (under the tongue) applications bypass the GI tract, as they are absorbed by the blood vessels in your mouth, getting the medication directly to the bloodstream.


That is not to say that oral applications do not work. In a 4-week test of sublingual B12 vs. oral B12, the oral group saw B12 levels rise by 164%. The sublingual group saw an even more impressive rise of 206% from baseline levels. 



Legere Pharmaceuticals has specially formulated sublingual sprays for optimal absorption:


Be-Thin contains Methylcobalamin B12, amino acids including Acetyl-L-Carnitine, and lipotropic nutrients Methionine, Inositol, and Choline.  


Myoden Spray contains Adenosine Monophosphate, a naturally occurring nucleotide which may have a positive impact on ATP production and fat utilization via AMPk activation.

Reference:
Sharabi, A., Cohen, E., Sulkes, J., Garty, M. (2003). Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route. NCBI. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884303/

Wednesday, June 21, 2017

How Adenosine Monophosphate Helps With Weight Management

The ratio between ATP and AMP is used as a way for a cell to sense how much energy is available and control the metabolic pathways that produce and consume ATP. The body attempts to maintain a specific ratio of AMP:ATP; when this ratio is out of balance, the cells adjust their metabolism accordingly. As the ratio increases either by increased levels of AMP or decreased levels of ATP, the body is signaled to produced more ATP. The AMP:ATP ratio is primarily regulated by an enzyme known as AMP-activated protein kinase (AMPK). When activated, AMPK sets in motion a series of events which switch cells from active ATP consumption to ATP production.



The presence of AMP leads to an increase in AMPK activity by approximately 5-fold, however AMP also plays an important role in regulating the level of phosphorylation of AMPK. "An increased AMP to ATP ratio leads to [...] increased phosphorylation and decreased dephosphorylation of AMPK. The phosphorylation of AMPK results in activation by at least 100-fold." This means that a relatively small increase in AMP can result in a dramatic increase of AMPK activity.

Adenosine monophosphate (AMP) is a naturally occurring cellular metabolite and is one of the four purine nucleotides responsible for protein synthesis. It is also a key component in certain enzyme reactions necessary for proper fat and carbohydrate metabolism. AMP appears to be beneficial for correcting low energy production due to mitochondrial dysfunction by increasing AMPK activity, a crucial regulator of cellular metabolism. AMPK activation has been shown to help reduce fat storage and triglyceride production while increasing fat burning and glucose uptake. When AMPK activity is impaired, glucose and fat begin to accumulate, leading to conditions such as increased belly fat, elevated blood sugar, insulin resistance, and high cholesterol.

Interested in learning more about AMP? Call us today at 1-800-528-3144 or visit www.legerepharm.com


References:
Stipanuk, M., Caudill, M. (2013). Biochemical, Physiological, and Molecular Aspects of Human Nutrition. St. Louis, MO: Saunders
King, M. (2017). AMPK: Master Metabolic Regulator. Retrieved from: http://themedicalbiochemistrypage.org/ampk.php

Monday, June 19, 2017

5-LOX: The Killer Enzyme

Click picture to enlarge

  • Excessive 5-LOX activity is associated with 7 of the leading 10 causes of death in the US, causing more than 1.5 million deaths annually.
  • The activity of an enzyme called 5-LOX leads to excessive release of pro-inflammatory molecules, including leukotrienes.
  • Extracts of boswellia are natural inhibitors of 5-LOX activity and have been used for millennia in treatment of diseases with inflammatory components.
  • An abundance of data demonstrates boswellia extracts' power to combat cardiovascular disease, neurodegeneration, cancer, and arthritis through 5-LOX inhibition and other anti-inflammatory characteristics
The 5-lipoxygenase (5-LOX) pathway is the major source of proinflammatory leukotrienes. 5-LOX breaks down arachidonic acid to pro-inflammatory compounds like leukotriene, a molecule that attacks joints, arterial walls, and other tissues. 5-LOX itself facilitates undesirable cell division changes.

New research into the Boswellia resin has shown that the Boswellic acids found within the resin are powerful inhibitors of pro-inflammatory molecules, and may prove to be more effective than NSAIDs. Specifically, the acid 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) has been identified for it's ability to inhibit the enzyme 5-LOX, intervening at the cellular level to block its unwanted effects. Inhibiting this enzyme restricts synthesis of inflammatory signaling leukotrienes.



Various experimentation has illustrated the effect of Boswellic acids on the 5-LOX enzyme:

- When Boswellia serrata was introduced into a 5-LOX test system, where suspensions of rat peritoneal neutrophils were stimulated by calcium and calcium ionophore A23187 to produce leukotrienes, Boswellia serrata significantly decreased production of leukotrienes and total 5-LOX products. There was no effect on cyclooxygenase (COX) activities10. "[Boswellia serrata] is the first selective, direct, non-competitive and non-redox-type inhibitor of 5-lipoxygenase, the key enzyme for leukotriene biosynthesis"

- "Boswellic acids inhibit the leukotriene biosynthesis in neutrophilic granulocytes by a non-redox, noncompetitive inhibition of 5-lipoxygenase [5-LOX]12. The effect is triggered by boswellic acids binding to the enzyme"


Legere Pharmaceuticals offers therapeutically dosed Boswella Capsules


10. Ammon, H.P.T., Safayhi, H., Mack, T., Sabieraj, J. (1993). Mechanism of antiinflammatory actions of curcumine and boswellic acids. Journal of Ethnopharmacology.
12.(2002). Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases. PubMed
14. Sherman, J. (2011). Neutralize a Lethal Enzyme. Life Extension. Retrieved from: http://www.lifeextension.com/Magazine/2011/SS/Neutralize-a-Lethal-Enzyme/Page-02

Thursday, June 15, 2017

Why Physicians Dispense

Americans spend more than 20 billion dollars on weight loss annually2. Many try to lose weight on their own with little success. Dieters typically make four or five attempts per year.

A large percentage of dieter's expenses goes towards supplements. It is estimated that 50% of Americans take multivitamins and 1 in 5 adults take some type of herbal supplement3. However, when patients are left to find products on their own they are often not getting what they need.

Recently tests were conducted on top-selling store brands of herbal supplements from retailers including GNC, Target, Walgreens, and Walmart. It was found that four out of five of the products tested did not contain any of the ingredients listed on the label4. "The tests showed that pills labeled medicinal herbs often contained little more than cheap fillers like powdered rice, asparagus and houseplants, and in some cases substances that could be dangerous to those with allergies."

"Three out of six herbal products at Target — ginkgo biloba, St. John’s wort and valerian root, a sleep aid — tested negative for the herbs on their labels. But they did contain powdered rice, beans, peas and wild carrots. And at GNC, the agency said, it found pills with unlisted ingredients used as fillers, like powdered legumes, the class of plants that includes peanuts and soybeans, a hazard for people with allergies."


This is just one of the many reasons why it is important for patients to use physician-recommended, therapeutically dosed products, such as those manufactured by Legere Pharmaceuticals.


In-office pharmaceutical dispensing improves the quality and therefore the cost effectiveness of losing weight by assuring that patients are getting the highest quality ingredients. Both the medical professional and the patient benefit from in-office pharmaceutical dispensing solutions. Dispensing in-office creates an additional revenue stream for the physician and saves the patient a trip to their local vitamin shop.

Medical Professional Benefits:

- Supplemental Revenue
- Increased Patient Compliance

Patient Benefits:

- Convenience
- Increased confidence (that they are getting what they need)





References:

2. (2012). 100 Million Dieters, $20 Billion: The Weight-Loss Industry by the Numbers. ABC News. Retrieved from: http://abcnews.go.com/Health/100-million-dieters-20-billion-weight-loss-industry/story?id=16297197

3. Scott, C. (2015). Americans Spend Billions on Vitamins and Herbs That Don’t Work. Healthline. Retrieved from: http://www.healthline.com/health-news/americans-spend-billions-on-vitamins-and-herbs-that-dont-work-031915

4. O'Connor, A. (2015). New York Attorney General Targets Supplements at Major Retailers. NY Times. Retrieved from: https://well.blogs.nytimes.com/2015/02/03/new-york-attorney-general-targets-supplements-at-major-retailers/?_r=0