Wednesday, June 21, 2017

How Adenosine Monophosphate Helps With Weight Management

The ratio between ATP and AMP is used as a way for a cell to sense how much energy is available and control the metabolic pathways that produce and consume ATP. The body attempts to maintain a specific ratio of AMP:ATP; when this ratio is out of balance, the cells adjust their metabolism accordingly. As the ratio increases either by increased levels of AMP or decreased levels of ATP, the body is signaled to produced more ATP. The AMP:ATP ratio is primarily regulated by an enzyme known as AMP-activated protein kinase (AMPK). When activated, AMPK sets in motion a series of events which switch cells from active ATP consumption to ATP production.



The presence of AMP leads to an increase in AMPK activity by approximately 5-fold, however AMP also plays an important role in regulating the level of phosphorylation of AMPK. "An increased AMP to ATP ratio leads to [...] increased phosphorylation and decreased dephosphorylation of AMPK. The phosphorylation of AMPK results in activation by at least 100-fold." This means that a relatively small increase in AMP can result in a dramatic increase of AMPK activity.

Adenosine monophosphate (AMP) is a naturally occurring cellular metabolite and is one of the four purine nucleotides responsible for protein synthesis. It is also a key component in certain enzyme reactions necessary for proper fat and carbohydrate metabolism. AMP appears to be beneficial for correcting low energy production due to mitochondrial dysfunction by increasing AMPK activity, a crucial regulator of cellular metabolism. AMPK activation has been shown to help reduce fat storage and triglyceride production while increasing fat burning and glucose uptake. When AMPK activity is impaired, glucose and fat begin to accumulate, leading to conditions such as increased belly fat, elevated blood sugar, insulin resistance, and high cholesterol.

Interested in learning more about AMP? Call us today at 1-800-528-3144 or visit www.legerepharm.com


References:
Stipanuk, M., Caudill, M. (2013). Biochemical, Physiological, and Molecular Aspects of Human Nutrition. St. Louis, MO: Saunders
King, M. (2017). AMPK: Master Metabolic Regulator. Retrieved from: http://themedicalbiochemistrypage.org/ampk.php

Monday, June 19, 2017

5-LOX: The Killer Enzyme

Click picture to enlarge

  • Excessive 5-LOX activity is associated with 7 of the leading 10 causes of death in the US, causing more than 1.5 million deaths annually.
  • The activity of an enzyme called 5-LOX leads to excessive release of pro-inflammatory molecules, including leukotrienes.
  • Extracts of boswellia are natural inhibitors of 5-LOX activity and have been used for millennia in treatment of diseases with inflammatory components.
  • An abundance of data demonstrates boswellia extracts' power to combat cardiovascular disease, neurodegeneration, cancer, and arthritis through 5-LOX inhibition and other anti-inflammatory characteristics
The 5-lipoxygenase (5-LOX) pathway is the major source of proinflammatory leukotrienes. 5-LOX breaks down arachidonic acid to pro-inflammatory compounds like leukotriene, a molecule that attacks joints, arterial walls, and other tissues. 5-LOX itself facilitates undesirable cell division changes.

New research into the Boswellia resin has shown that the Boswellic acids found within the resin are powerful inhibitors of pro-inflammatory molecules, and may prove to be more effective than NSAIDs. Specifically, the acid 3-O-acetyl-11-keto-beta-boswellic acid (AKBA) has been identified for it's ability to inhibit the enzyme 5-LOX, intervening at the cellular level to block its unwanted effects. Inhibiting this enzyme restricts synthesis of inflammatory signaling leukotrienes.



Various experimentation has illustrated the effect of Boswellic acids on the 5-LOX enzyme:

- When Boswellia serrata was introduced into a 5-LOX test system, where suspensions of rat peritoneal neutrophils were stimulated by calcium and calcium ionophore A23187 to produce leukotrienes, Boswellia serrata significantly decreased production of leukotrienes and total 5-LOX products. There was no effect on cyclooxygenase (COX) activities10. "[Boswellia serrata] is the first selective, direct, non-competitive and non-redox-type inhibitor of 5-lipoxygenase, the key enzyme for leukotriene biosynthesis"

- "Boswellic acids inhibit the leukotriene biosynthesis in neutrophilic granulocytes by a non-redox, noncompetitive inhibition of 5-lipoxygenase [5-LOX]12. The effect is triggered by boswellic acids binding to the enzyme"


Legere Pharmaceuticals offers therapeutically dosed Boswella Capsules


10. Ammon, H.P.T., Safayhi, H., Mack, T., Sabieraj, J. (1993). Mechanism of antiinflammatory actions of curcumine and boswellic acids. Journal of Ethnopharmacology.
12.(2002). Boswellic acids (components of frankincense) as the active principle in treatment of chronic inflammatory diseases. PubMed
14. Sherman, J. (2011). Neutralize a Lethal Enzyme. Life Extension. Retrieved from: http://www.lifeextension.com/Magazine/2011/SS/Neutralize-a-Lethal-Enzyme/Page-02

Thursday, June 15, 2017

Why Physicians Dispense

Americans spend more than 20 billion dollars on weight loss annually2. Many try to lose weight on their own with little success. Dieters typically make four or five attempts per year.

A large percentage of dieter's expenses goes towards supplements. It is estimated that 50% of Americans take multivitamins and 1 in 5 adults take some type of herbal supplement3. However, when patients are left to find products on their own they are often not getting what they need.

Recently tests were conducted on top-selling store brands of herbal supplements from retailers including GNC, Target, Walgreens, and Walmart. It was found that four out of five of the products tested did not contain any of the ingredients listed on the label4. "The tests showed that pills labeled medicinal herbs often contained little more than cheap fillers like powdered rice, asparagus and houseplants, and in some cases substances that could be dangerous to those with allergies."

"Three out of six herbal products at Target — ginkgo biloba, St. John’s wort and valerian root, a sleep aid — tested negative for the herbs on their labels. But they did contain powdered rice, beans, peas and wild carrots. And at GNC, the agency said, it found pills with unlisted ingredients used as fillers, like powdered legumes, the class of plants that includes peanuts and soybeans, a hazard for people with allergies."


This is just one of the many reasons why it is important for patients to use physician-recommended, therapeutically dosed products, such as those manufactured by Legere Pharmaceuticals.


In-office pharmaceutical dispensing improves the quality and therefore the cost effectiveness of losing weight by assuring that patients are getting the highest quality ingredients. Both the medical professional and the patient benefit from in-office pharmaceutical dispensing solutions. Dispensing in-office creates an additional revenue stream for the physician and saves the patient a trip to their local vitamin shop.

Medical Professional Benefits:

- Supplemental Revenue
- Increased Patient Compliance

Patient Benefits:

- Convenience
- Increased confidence (that they are getting what they need)





References:

2. (2012). 100 Million Dieters, $20 Billion: The Weight-Loss Industry by the Numbers. ABC News. Retrieved from: http://abcnews.go.com/Health/100-million-dieters-20-billion-weight-loss-industry/story?id=16297197

3. Scott, C. (2015). Americans Spend Billions on Vitamins and Herbs That Don’t Work. Healthline. Retrieved from: http://www.healthline.com/health-news/americans-spend-billions-on-vitamins-and-herbs-that-dont-work-031915

4. O'Connor, A. (2015). New York Attorney General Targets Supplements at Major Retailers. NY Times. Retrieved from: https://well.blogs.nytimes.com/2015/02/03/new-york-attorney-general-targets-supplements-at-major-retailers/?_r=0



Wednesday, June 14, 2017

Magnesium & Insulin Resistance

Magnesium is a mineral involved in over 300 metabolic processes in the body. Every cell in our body depends on magnesium to function and magnesium plays a key role in keeping these cells functioning optimally.

Despite the importance of magnesium, most Americans do not obtain enough magnesium from dietary sources. A study published in the Journal of the American Medical Association found that:

". . .a significant number of patients with serum magnesium abnormalities are clinically unrecognized and demonstrate the efficacy of routine serum magnesium measurements."

New research has revealed that insulin receptors are another of the body's functions that rely on magnesium to function and respond to insulin properly. Additionally, high levels on insulin can increase the amount of magnesium excreted from the kidneys. This results in a vicious cycle in which lack of magnesium causes insulin resistance and excessive insulin reduces levels of magnesium.

A 2015 study published in the journal Diabetes Metabolism evaluated the efficacy of magnesium supplementation on individuals with prediabetes and low magnesium:

"At the end of the trial, significant changes compared to placebo were seen. The researchers found an 11.6% reduction in fasting glucose, a 8.8% decrease in post-meal glucose, a 30.5% decrease in insulin resistance scores, and a 26.7% decrease in triglycerides."







References:
Faloon, C. (2017). Magnesium Deficiency Increases Insulin Resistance. Life Extension. retrieved from: http://www.lifeextension.com/Magazine/2017/7/Magnesium-Deficiency-Increases-Insulin-Resistance/Page-01

(2009). Prediabetes & Insulin Resistance. NIH. retrieved from: https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/prediabetes-insulin-resistance

Tuesday, April 4, 2017

Private Labeling



As the supplement market continues to grow, it becomes increasingly difficult for consumers to determine which products are worth their while. In order to gain an edge in the marketplace and help reduce the confusion for your patients, private labeling is an easy solution.

- Separate yourself from the competition

A unique label will help your products stand out from products your patients might find online or at a health food store.

- Establish a brand your patients can trust

Putting your name on the bottle can create a more professional image which extends the physicians' credibility to the products you recommend. This gives the patients more confidence and may even inspire greater compliance.

- Expand the reach of your practice

Private labeling can lead to more patient referrals. If a patient recommends one of your products to their friend(s), they will know to get it from you - as your contact information will be on the bottle - if they want to experience the same results.

Legere Pharmaceuticals offers a private label that can include your name, practice, logo, address, and phone number. You have the choice of up to two (2) colors at no additional cost. You may choose our standard design or create your own (a setup fee may apply).

Private labeling can be an advantage to your practice. It promotes doctor/patient confidence and return visits. Call our customer service line for more information on how to privatize your practice today. 1-800-528-3144