Researchers have discovered a molecular pathway for stimulating the body to burn fat. This discovery could be helpful in fighting obesity, diabetes and cardiovascular disease.
To test this pathways, mice that have been genetically engineered to over-express this molecular pathway were fed a high-fat diet for 14 weeks. At the end of the study, the normal mice had rapidly gained weight but the genetically modified mice remained slim and did not have the same elevated insulin and triglyceride levels that the normal mice did. Further analysis found that the genetically engineered mice were in fact burning more fat.
What is this new miraculous molecular pathway responsible for these result? AMPK (Adenosine Monophosphate-Activated Protein Kinase). Researchers found that by boosting AMPK activity, the proteins PGC-1α and ERRα were activated - increasing the number and work rate of the cells' mitochondria. The end result is a metabolic reprogramming that switches the body from a fat storage machine to a fat burning machine.
Activated AMPK promotes all the processes needed to maintain a youthful profile. To further test the anti-aging properties of AMPK, researchers used fruit flies that, similar to the aforementioned mice, were genetically engineered to have higher levels of AMPK activity. The research found that the modified flies lived up to one-third longer than normal flies. "The life span benefit of these mutations depends upon increased AMP:ATP and ADP:ATP ratios and adenosine monophosphate-activated protein kinase (AMPK). Transgenic expression of AMPK in adult fat body or adult muscle, key metabolic tissues, extended life span" (Stenesen, 2013).
The mechanism used to engineer increased AMPK activity in these test subjects was to genetically modify the flies to produce more adenosine monophosphate (AMP). As the name implies, increased levels of AMP results in increased levels of AMPK. However, one does not require genetic mutations to achieve the results of increased AMPK activity. Researchers have now confirmed that consistent dosages of oral AMP results in increased AMPK activity. In a study using lab rats fed supplemental AMP, "AMP effectively improved hypertension, plasma triglyceride, and HDL-cholesterol, glucose, kidney function parameters, hepatic lipid, enhances plasma nitric oxide, and plasma adiponectin..." (Ardiansyah, 2011). The researchers found that AMP up-regulated mRNA expression levels, affecting genes involved in B-oxidation, fatty acid synthesis, and AMPK.
It is clear that AMPK activity is desirable for reducing the unwanted effects of aging. AMPK activity can be increased through exercise and proper nutrition however as we age, AMPK activity declines. This decline can be reduced and possibly even reversed through pharmacologic AMPK activation such as that achieved through supplemental oral AMP.
There are many products that claim to be AMPK activators, but only AMP has been proven in laboratory settings to directly increase AMPK activity via oral administration. For the highest quality form of AMP, ask your doctor about MYODEN from Legere Pharmaceuticals.
Ming, Yan., et. al. (2016). Chronic AMPK activation... Genes & Development.
Stenesen, D., Suh, JM., Seo, J., Yu, K., Lee, K.S., Min, K.J., & Graff, J.M. (2013). Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. Cellular Metabolism. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/23312286
Ardiansyah, Shirakawa, D., Koseki, H., Saori, T., Yoshinobu, A., & Michio, K. (2011). Novel Effect of Adenosine 5′-Monophosphate on Ameliorating Hypertension and the Metabolism of Lipids and Glucose in Stroke-Prone Spontaneously Hypertensive Rats. Journal of Agricultural and Food Chemistry.